| Chemical Properties | Back Directory | [Melting point ]
236-240℃ | [Boiling point ]
678.5±55.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
solid
| [pka]
8.53±0.70(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Description]
Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM). It also acts as an endothelin receptor antagonist and has antiosteoporotic activities. Certain effects are thought to be mediated through inhibition of proteasomal degradation of proteins. | [Uses]
Kendomycin is an unusual macrocyclic metabolite containing a rare quinone methide group. Kendomycin is a potent antibacterial agent against Gram positive and Gram negative bacteria, including MRSA strains, also displaying antitumour activity. Kendomycin is a potent endothelin receptor agonist and demonstrates antiosteoporotic activity. | [Definition]
ChEBI: Kendomycin is a member of benzofurans. | [storage]
Store at -20°C | [References]
[1] KEVIN B. BAHNCK Scott D R. Formal Synthesis of (?)-Kendomycin Featuring a Prins-Cyclization To Construct the Macrocycle[J]. Journal of the American Chemical Society, 2008, 130 39: 13177-13181. DOI: 10.1021/ja805187p |
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| Company Name: |
Lynnchem
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| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
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