| Identification | Back Directory | [Name]
N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide | [CAS]
183896-00-6 | [Synonyms]
Biotin-C3-PEG3-C3-NH2
Biotin-C1-PEG3-C1-NH2
N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4R,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | [Molecular Formula]
C20H38N4O5S | [MOL File]
183896-00-6.mol | [Molecular Weight]
446.6 |
| Chemical Properties | Back Directory | [Boiling point ]
715.3±60.0 °C(Predicted) | [density ]
1.139±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
13.90±0.40(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Park S, et al. One-step, aid-mediated method for modification of glass surfaces with N-hydroxysuccinimide esters and its application to the construction of microarrays for studies of biomolecular interactions. Bioconjug Chem. 2010 Jul 21;21(7):1246-53. DOI:10.1021/bc100042j |
|
|