| Identification | Back Directory | [Name]
Rimeporide | [CAS]
187870-78-6 | [Synonyms]
EMD-87580
Rimeporide
EMD-87580 >=98% (HPLC)
N-carbamimidoyl-2-methyl-4,5-bis(methylsulfonyl)benzamide
N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide
Benzamide, N-(aminoiminomethyl)-2-methyl-4,5-bis(methylsulfonyl)- | [Molecular Formula]
C11H15N3O5S2 | [MOL File]
187870-78-6.mol | [Molecular Weight]
333.38 |
| Chemical Properties | Back Directory | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO : 20 mg/mL (59.99 mM) | [form ]
powder | [pka]
10.50±0.46(Predicted) | [color ]
white to beige | [InChI]
1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15) | [InChIKey]
GROMEQPXDKRRIE-UHFFFAOYSA-N | [SMILES]
NC(NC(C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C)=O)=N |
| Hazard Information | Back Directory | [Uses]
EMD-87580 has been used as a selective and potent sodium-hydrogen antiporter 1 (NHE-1) inhibitor in cardiac ventricular myocytes to test its effect on the hypertrophic response. | [Biochem/physiol Actions]
EMD-87580 is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. EMD-87580 has shown cardioprotective effects, and has been investigated as a possible treatment for Duchenne′s muscular dystrophy. |
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Sigma-Aldrich
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