| Identification | Back Directory | [Name]
Boc-Val-Ala-PAB | [CAS]
1884577-99-4 | [Synonyms]
Boc-Val-Ala-PAB
(S)-2-(Boc-amino)-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide | [Molecular Formula]
C20H31N3O5 | [MOL File]
1884577-99-4.mol | [Molecular Weight]
393.48 |
| Chemical Properties | Back Directory | [Boiling point ]
653.7±55.0 °C(Predicted) | [density ]
1.166±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.26±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Boc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Boc-Val-Ala-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate (ADCs)[1][2]. | [References]
[1] HP Wilson, et al. Pyrrolobenzodiazepines and conjugates thereof: World Intellectual Property Organization, WO2016037644. 2016-03-17.
[2] HP Wilson, et al. Preparation of pyrrolobenzodiazepine dimers and their conjugates with cell binding agents, especially pyrrolobenzodiazepine dimer drug linker antibody conjugates and their use for treating proliferative diseases, particularly cancer: World Intellectual Property Organization, WO2016038383. 2016-03-17 |
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