| Identification | Back Directory | [Name]
ELA-14 (human) | [CAS]
1886973-05-2 | [Synonyms]
ELA-14 (human)
Elabela(19-32)
L-Proline, 5-oxo-L-prolyl-L-arginyl-L-arginyl-L-cysteinyl-L-methionyl-L-prolyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-phenylalanyl- | [Molecular Formula]
C75H119N25O17S2 | [MDL Number]
MFCD31382540 | [MOL File]
1886973-05-2.mol | [Molecular Weight]
1707.03 |
| Hazard Information | Back Directory | [Uses]
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1]. | [in vivo]
Elabela(19-32) (analogue 3) is rapidly metabolized in rat plasma (t1/2<2 min)[1].
| [References]
[1] Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72. DOI:10.1021/acs.jmedchem.5b01549 |
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