| Identification | Back Directory | [Name]
6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol | [CAS]
189057-68-9 | [Synonyms]
ZINC05626394
ZINC05626394 >=98% (HPLC)
6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol | [Molecular Formula]
C11H10N2OS2 | [MDL Number]
MFCD15201295 | [MOL File]
189057-68-9.mol | [Molecular Weight]
250.34 |
| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 25mg/mL, clear | [form ]
powder | [pka]
7.32±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
ZINC05626394 is a Cytochrome b5 reductase 3 (CYB5R3) inhibitor. It acts by increasing NO bioavailability. | [Uses]
ZINC05626394 is a cytochrome b5 reductase 3 inhibitor with activity by increasing nitric oxide bioavailability. ZINC05626394 may have potential applications in anti-cancer suppression, especially in combination with antibody drug conjugates (ADCs) and immune checkpoint inhibitors. The efficacy of ZINC05626394 may be limited by different mechanisms, including antigen-related resistance and failure of endocytosis[1]. | [References]
[1] Mechanisms of Resistance to Antibody-Drug Conjugates DOI:10.1074/jbc.M114.629964 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Key Organics Ltd.
|
| Tel: |
+44 (0) 1840-212137 |
| Website: |
www.keyorganics.net |
|