| Identification | Back Directory | [Name]
3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester | [CAS]
443872-20-6 | [Synonyms]
ZINC08438472
ZINC-08438472
ZINC 08438472
3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester | [Molecular Formula]
C25H25NO8S | [MOL File]
443872-20-6.mol | [Molecular Weight]
499.53 |
| Hazard Information | Back Directory | [Description]
ZINC08438472 is a selective agonist of peroxisome proliferator activated receptors-α (PPAR-α). | [Uses]
ZINC08438472 is a potent and selective peroxisome proliferator activated receptors-α (PPAR-α) agonist with an EC50 value of 12.1 nM. ZINC08438472 is promising for research of diabetes, hyperlipidaemia and inflammatory disorders[1]. | [References]
[1] Gangwal RP, et al. Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-α (PPAR-α) agonists. Bioorg Med Chem Lett. 2015 Jan 15;25(2):270-5. DOI:10.1016/j.bmcl.2014.11.052 |
|
|