| Identification | Back Directory | [Name]
salvigenin | [CAS]
19103-54-9 | [Synonyms]
5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
5-Hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)- | [Molecular Formula]
C18H16O6 | [MDL Number]
MFCD00238678 | [MOL File]
19103-54-9.mol | [Molecular Weight]
328.32 |
| Chemical Properties | Back Directory | [Melting point ]
188 °C | [Boiling point ]
535.9±50.0 °C(Predicted) | [density ]
1.314±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
6.33±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Salvigenin is a neuroprotective agent used in the treatment of neurodegenerative diseases acting through oxidative stress on cells. | [Definition]
ChEBI: Salvigenin is a trimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4', 6, and 7 are replaced by methoxy groups. It has a role as an autophagy inducer, an apoptosis inhibitor, an antilipemic drug, an immunomodulator, an antineoplastic agent, a neuroprotective agent, a hypoglycemic agent and a plant metabolite. It is a trimethoxyflavone and a monohydroxyflavone. It is functionally related to a scutellarein. | [in vivo]
Salvigenin (0-9.68 μg/mouse/day; i.p.; 4 or 12 days) shows antitumor and immunomodulatory effects on tumor bearing mice[2]. | Animal Model: | MCF-7 cell bearing inbred female Balb/c mice, aged from six to eight weeks[2] | | Dosage: | 3.65, 5.85 and 9.68 μg/mouse/day for four days or 12 days | | Administration: | Intraperitoneal injection | | Result: | Showed a significant increase in DTH response in a dose-dependent manner. Significantly decreased the rate of tumor growth, increased lymphocyte proliferation index, increased the level of IFN-γ and decreased IL-4 production. Exhibited a significant decrease of the splenic CD4+CD25+Foxp3+ T lymphocytes. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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