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192927-92-7

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192927-92-7 Structure

192927-92-7 Structure
IdentificationBack Directory
[Name]

LY310762
[CAS]

192927-92-7
[Synonyms]

CS-195
LY 310762 HCl
LY310762;LY-310762
LY310762 USP/EP/BP
LY-310,762 HYDROCHLORIDE
1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one
1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one,hydrochloride
1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride
1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride
3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride
2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride
[Molecular Formula]

C24H27O2N2FHCl
[MDL Number]

MFCD03457395
[MOL File]

192927-92-7.mol
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at RT
[solubility ]

DMSO: 10 mg/mL with heating, soluble
[form ]

white powder
[color ]

White to off-white
[CAS DataBase Reference]

192927-92-7
Safety DataBack Directory
[Symbol(GHS) ]

Skull and Crossbones (GHS06)
GHS06
[Signal word ]

Danger
[Hazard statements ]

H301+H331-H315-H319-H335-H227
[Precautionary statements ]

P501-P261-P270-P210-P271-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P310+P330-P304+P340+P311-P403+P233-P403+P235-P405
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

LY-310762 Hydrochloride is a selective and potent SR-1D and 5-hydroxytryptamine (5-HT1D) receptor-preferring antagonist.
[Definition]

ChEBI:LY-310762 hydrochloride is a hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It contains a LY-310762(1+).
[Biological Activity]

5-HT 1D -preferring receptor antagonist (EC 50 = 31 nM). Displays no activity on 5-HT transport.
[in vivo]

LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo[1].
LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model[2].

Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan)[1].
Dosage:10 mg/kg
Administration:Intraperitoneal injection; single
Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.
Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model)[2].
Dosage:1 mg/kg
Administration:Intravenous injection; single
Result:Completely abolished 5-HT vasodilator effects.
[IC 50]

5-HT1D Receptor: 249 nM (Ki)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

LY310762(192927-92-7)1HNMR
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