| Identification | Back Directory | [Name]
Biotin-PEG12-NHS ester | [CAS]
1934296-88-4 | [Synonyms]
2，5-Dioxopyrrolidin-1-yl 41-oxo-45-((3aS，4S，6aR)-2-oxohexahydro-1H-thieno[3，4-d]imidazol-4-yl)-4，7，10，13，16，19，22，25，28，31，34，37-dodecaoxa-40-azapentatetracontan-1-oate
4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxa-40-azapentatetracontanoic acid, 45-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-41-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C41H72N4O18S | [MOL File]
1934296-88-4.mol | [Molecular Weight]
941.09 |
| Chemical Properties | Back Directory | [density ]
1.26±0.1 g/cm3(Predicted) | [solubility ]
DMSO: 100 mg/mL (106.26 mM) | [form ]
Oil | [pka]
13.90±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Biotin-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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