| Identification | Back Directory | [Name]
15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester | [CAS]
459426-22-3 | [Synonyms]
NHS-PEG4-Biotin
Biotin-PEG4-NHS
Biotin-PEG4-SPA
NHS-dPEG4-Biotin
NHS-dPEG(R)4-biotin
Biotin-PEG4-NHS ester
(+)-Biotin-PEG4-NHS Ester
Biotin-PEG4-NHS-propionate
Biotin-PEG4-CH2CH2COONHS Ester
Biotin PEG4 succinimidyl ester
15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester
21-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-4,7,10,13-tetraoxa-16-azaheneicosanoic acid 2,5-dioxo-1-pyrrolidinyl ester
4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C25H40N4O10S | [MDL Number]
MFCD08458915 | [MOL File]
459426-22-3.mol | [Molecular Weight]
588.67 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DMF, DCM | [form ]
solid or viscous liquid | [pka]
13.90±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
Biotin-PEG4-NHS is an amine reactive reagent that contains biotin linked via a four-unit PEG spacer to N-hydroxysuccinimide (NHS), which facilitates the coupling of biotin to primary amines.1 Biotin-PEG4-NHS has been used in the biotinylation of proteins and antibodies.2,3 | [Uses]
Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reagent type: cross-linking reagent
reaction type: Biotinylations
reactivity: amine reactive
reagent type: linker | [IC 50]
PEGs | [References]
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
|
|