| Identification | Back Directory | [Name]
ZEN-3219 | [CAS]
1952264-34-4 | [Synonyms]
ZEN-3219
ZEN3219,ZEN 3219
2(1H)-Pyridinone, 5-(3,5-dimethyl-4-isoxazolyl)-1-[[4-(2-oxiranyl)phenyl]methyl]- | [Molecular Formula]
C19H18N2O3 | [MDL Number]
MFCD32062746 | [MOL File]
1952264-34-4.mol | [Molecular Weight]
322.36 |
| Chemical Properties | Back Directory | [Boiling point ]
588.3±50.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-0.93±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4[1]. | [IC 50]
BRD4 (BD1): 0.48 μM (IC50); BRD4 (BD2): 0.16 μM (IC50); BRD4(BD1BD2): 0.47 μM (IC50) | [References]
[1] Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211. DOI:10.1021/acs.jmedchem.8b00666 |
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