| Identification | Back Directory | [Name]
2(1H)-Pyridinone, 5-(3,5-dimethyl-4-isoxazolyl)-1-(phenylmethyl)- | [CAS]
1616400-50-0 | [Synonyms]
2(1H)-Pyridinone, 5-(3,5-dimethyl-4-isoxazolyl)-1-(phenylmethyl)- | [Molecular Formula]
C17H16N2O2 | [MOL File]
1616400-50-0.mol | [Molecular Weight]
280.32 |
| Hazard Information | Back Directory | [Description]
ZEN-2759 is BRD4(BD1) inhibitor. | [Uses]
ZEN-2759 is a potent BET (Bromodomain and Extra-Terminal Domain) inhibitor, with IC50 values of 0.23, 0.08 and 0.28 μM for BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2), respectively[1]. | [IC 50]
BRD4 (BD2): 0.08 μM (IC50); BRD4 (BD1): 0.23 μM (IC50); BRD4(BD1BD2): 0.28 μM (IC50) | [References]
[1] Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211. DOI:10.1021/acs.jmedchem.8b00666 |
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