| Identification | Back Directory | [Name]
ZEN-3411 | [CAS]
1952264-36-6 | [Synonyms]
ZEN-3411
1H-Benzimidazol-4-amine, 6-(3,5-dimethyl-4-isoxazolyl)-1-[[4-(2-oxiranyl)phenyl]methyl]- | [Molecular Formula]
C21H20N4O2 | [MDL Number]
MFCD32062748 | [MOL File]
1952264-36-6.mol | [Molecular Weight]
360.41 |
| Hazard Information | Back Directory | [Description]
ZEN-3411 is a BET inhibitor for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3411 can be used to form PROTACs to induce degradation of BRD4. | [Uses]
ZEN-3411 is a BET inhibitor with IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3411 can be used to form PROTACs to induce degradation of BRD4[1]. | [IC 50]
BRD4 (BD1): 0.05 μM (IC50); BRD4 (BD2): 0.05 μM (IC50); BRD4(BD1BD2): 0.06 μM (IC50) | [References]
[1] Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211. DOI:10.1021/acs.jmedchem.8b00666 |
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