| Identification | Back Directory | [Name]
Anavex 2-73 | [CAS]
195615-84-0 | [Synonyms]
CS-2759
Anavex 2-73
Blarcamesine
Anavex2-73 HCl
AVex-73 hydrochL
AE-37 HYDROCHLORIDE
AN2/AVEX-73 HCL SALT
AVex-73 hydrochloride
Anavex 2-73(ANAVEX2-73)
Blarcamesine hydrochloride
AVex-73 hydrochloride(AE-37)
AN2/AVex-73 hydrochloride salt
Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride salt
AE-37; AVEX-73; ANAVEX-2-73; ANAVEX-273; AE37; AVEX73; ANAVEX273; AE 37; AVEX 73; ANAVEX 2 73; ANAVEX 273; BLARCAMESINE | [Molecular Formula]
C19H24ClNO | [MDL Number]
MFCD30146449 | [MOL File]
195615-84-0.mol | [Molecular Weight]
317.86 |
| Chemical Properties | Back Directory | [Melting point ]
165 - 168°C | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C19H23NO.ClH/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12,18H,13-15H2,1-2H3;1H | [InChIKey]
FEQOLYDPQKHFTD-UHFFFAOYSA-N | [SMILES]
C(C1CCOC1(C1C=CC=CC=1)C1C=CC=CC=1)N(C)C.Cl |
| Hazard Information | Back Directory | [Uses]
Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine Hydrochloride is a useful therapeutic in the treatment of humans suffering from insomnia, anxiety, or agitation.Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine Hydrochloride is also used in pharmacological studies such as the anti-amnesic and neuroprotective potentials of mixed muscarinic receptor/σ1 ligand ANAVEX2-73 as novel aminotetrahydrofuran deriv. | [in vivo]
The pre-administration of Blarcamesine leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg[1]. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1?mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1?mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1?mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested[2]. | [IC 50]
Sigma 1 Receptor |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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