| Identification | More | [Name]
2-Amino-6-bromopyridine | [CAS]
19798-81-3 | [Synonyms]
2A6BP
2-AMINO-6-BROMOPYRIDINE
6-BROMO-2-AMINOPYRIDINE
6-BROMO-2-PYRIDINAMINE
6-BROMO-PYRIDIN-2-YLAMINE
Aminobromopyridine
2-Bromo-6-Aminopyridine
6-Bromopyridin-2-amine
2-AMINO-6-BROMOPIPERIDINE
2-AMINO-6-BROMOPIPERIDINE 98%
2-AMINO-6-BROMO-PHENOL
6-bromopyridine-2-amino
6-Bromopyridine-2-amine | [EINECS(EC#)]
606-385-7 | [Molecular Formula]
C5H5BrN2 | [MDL Number]
MFCD00137843 | [Molecular Weight]
173.01 | [MOL File]
19798-81-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Slightly yellow to light brown powder | [Melting point ]
88-91 °C (lit.) | [Boiling point ]
273.0±20.0 °C(Predicted) | [density ]
1.710±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Very Slightly) | [form ]
Powder | [pka]
2.73±0.24(Predicted) | [color ]
Slightly yellow to light brown | [Water Solubility ]
Slightly soluble in water. | [Detection Methods]
HPLC | [InChI]
InChI=1S/C5H5BrN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8) | [InChIKey]
BKLJUYPLUWUEOQ-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(Br)=CC=C1 | [CAS DataBase Reference]
19798-81-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Slightly yellow to light brown powder | [Uses]
2-Amino-6-bromopyridine is a disubstituted pyridine used as a building block in the preparation of nitrogen containing bicyclic and polycylic compounds. | [Application]
2-Amino-6-bromopyridine is an important raw material for the synthesis of:
2-amino-6-diethylaminopyridine
2,6-di-(methylamino)-pyridine
3-(6-bromopyridin-2-yl)-2-(2,6-difluorophenyl)-1,3-thiazolidin-4-one
N-(6-bromopyridin-2-yl)dodecylamide
2-bromo-6-iodopyridine
Employed in an efficient one-pot synthesis of 7-azaindoles.
Used in the synthesis of anti-HIV agents.
| [General Description]
2-Amino- 6-bromopyridine has been synthesized from epichlorohydrin. | [Synthesis]
14.1 Preparation of 6-bromo-2-aminopyridine
In a steel autoclave equipped with a glass liner, 10.00 g of 2,6-dibromopyridine (42.2 mmol) was suspended in 50 mL of concentrated ammonia. The autoclave was sealed and heated to 190°C using a heating jacket and maintained for 6 hours (pressure was raised to about 25 bar). After the autoclave was cooled and depressurized, the reaction mixture was mixed with 100 mL of ethyl acetate for phase separation. The aqueous phase was extracted twice with ethyl acetate, 100 mL each. the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in 250 mL of a solvent mixture of cyclohexane/ethyl acetate (1:1, v/v) to remove the by-product 2,6-diaminopyridine. Subsequently, the solution was filtered through a short silica gel column (5 x 20 cm) and washed again with 250 mL of cyclohexane/ethyl acetate (1:1, v/v) mixed solvent. After removal of the solvent under reduced pressure, the residue was sublimated at 90°C and 10-1 mbar to give 6.49 g (37.5 mmol, 88.9% yield) of 6-bromo-2-aminopyridine as a white solid. | [References]
[1] Patent: US2004/199024, 2004, A1. Location in patent: Page 17
[2] Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 381,386, 949
[3] Chemical Communications, 2010, vol. 46, # 6, p. 925 - 927 |
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