| Identification | Back Directory | [Name]
N33-TEG-COOH | [CAS]
201467-81-4 | [Synonyms]
N3-TEG-COOH
N33-TEG-COOH
N3-PEG4-CH2COOH
14-Azido-3,6,9,12-tetraoxatetradecanoic acid
14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid
14-Azido-3,6,9,12-tetraoxatetradecanoic acid solution
Acetic acid, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-
2-{2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethoxy}acetic acid solution
14-Azido-3,6,9,12-tetraoxatetradecanoic acid solution - 0.5M solution in tert-butyl methyl ether
14-Azido-3,6,9,12-tetraoxatetradecanoic acid solution ~0.5 M in tert-butyl methyl ether, >=90% (HPLC) | [Molecular Formula]
C10H19N3O6 | [MDL Number]
MFCD20134123 | [MOL File]
201467-81-4.mol | [Molecular Weight]
277.28 |
| Chemical Properties | Back Directory | [density ]
0.750-0.850 g/mL at 20 °C | [Fp ]
-33℃ | [storage temp. ]
2-8°C | [form ]
Liquid | [color ]
Colorless to light yellow | [BRN ]
7928855 | [InChI]
InChI=1S/C10H19N3O6/c11-13-12-1-2-16-3-4-17-5-6-18-7-8-19-9-10(14)15/h1-9H2,(H,14,15) | [InChIKey]
YHTABJLSZLHRFV-UHFFFAOYSA-N | [SMILES]
O(CCOCC(=O)O)CCOCCOCCN=[N+]=[N-] |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H225-H315 | [Precautionary statements ]
P210 | [Hazard Codes ]
F,Xi | [Risk Statements ]
11-38 | [Safety Statements ]
16 | [RIDADR ]
UN 2398 3 / PGII | [WGK Germany ]
2 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Flam. Liq. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Description]
Azido-PEG4-CH2CO2H is a very popular click chemistry linker containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU). | [reaction suitability]
reaction type: click chemistry
reagent type: linker | [IC 50]
PEGs | [References]
[1] Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. DOI:10.1021/acschembio.5b00216 |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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