ChemicalBook--->CAS DataBase List--->2021179-11-1

2021179-11-1

2021179-11-1 Structure

2021179-11-1 Structure
IdentificationBack Directory
[Name]

MMAE-SMCC
[CAS]

2021179-11-1
[Synonyms]

MMAE-SMCC
[Molecular Formula]

C58H89N7O14S
[MDL Number]

MFCD34469933
[MOL File]

2021179-11-1.mol
[Molecular Weight]

1140.43
Chemical PropertiesBack Directory
[density ]

1.26±0.1 g/cm3(Predicted)
[solubility ]

DMSO : 220 mg/mL (192.91 mM; Need ultrasonic)
[form ]

Solid
[pka]

13.59±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MMAE-SMCC is a agent-linker conjugate for ADC. MMAE-SMCC is composed of a potent mitotic and a tubulin inhibitor MMAE (HY-15162) and a linker SMCC to make antibody agent conjugate[1].
[IC 50]

Auristatin
[References]

[1] Tang Y, et al. Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control. Sci Rep. 2017 Aug 10;7(1):7763. DOI:10.1038/s41598-017-08151-2
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