| Chemical Properties | Back Directory | [Boiling point ]
394.7±42.0 °C(Predicted) | [density ]
1.175±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO : 100 mg/mL (363.28 mM; Need ultrasonic) | [form ]
Solid | [pka]
15.11±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3]. | [in vivo]
GET73 (5-50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test[3].
| Animal Model: | Male SD rats (200-300?g and 300–350?g)[3] | | Dosage: | 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg | | Administration: | Oral gavage | | Result: | Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test. |
| [storage]
Store at -20°C | [References]
[1] Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35. DOI:10.1093/alcalc/agv094
[2] Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71. DOI:10.1016/s1734-1140(11)70700-9
[3] Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8. DOI:10.3389/fpsyt.2012.00008 |
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| Company Name: |
Qingfeng Chem
|
| Tel: |
18672943286 |
| Website: |
https://www.whqfchem.com |
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