| Identification | Back Directory | [Name]
1H-Indole-3-acetonitrile, α-(5-isoquinolinylmethylene)-, (αZ)- | [CAS]
2055405-95-1 | [Synonyms]
PIP4K-IN-a131
1H-Indole-3-acetonitrile, α-(5-isoquinolinylmethylene)-, (αZ)- | [Molecular Formula]
C20H13N3 | [MDL Number]
MFCD32708538 | [MOL File]
2055405-95-1.mol | [Molecular Weight]
295.34 |
| Chemical Properties | Back Directory | [Boiling point ]
562.2±45.0 °C(Predicted) | [density ]
1.308±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.75±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC50s of 1.9 μM and 0.6 μM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways[1]. | [References]
[1] Mayumi Kitagawa, et al. Dual Blockade of the Lipid Kinase PIP4Ks and Mitotic Pathways Leads to Cancer-Selective Lethality. Nat Commun. 2017 Dec 19;8(1):2200. DOI:10.1038/s41467-017-02287-5 |
|
|