| Chemical Properties | Back Directory | [Boiling point ]
719.0±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 110 mg/mL (232.79 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
11.52±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
JH-XI-05-01 blocks phosphorylation of SR proteins. JX-XI-05-01 is a covalent SRPK1/2 inhibitor that potently converts VEGF from pro-angiogenic to anti-angiogenic isoform. | [Uses]
SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. | [in vivo]
SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis in a CNV mouse model through VEGF alternative splicing[1]. | Animal Model: | Mice[1] | | Dosage: | 50 nM, 300 nM, 1 μL | | Administration: | Intravitreal injection, 5 times | | Result: | SRPKIN-1-treated mice is significantly suppressed in a dose-dependent manner based upon measurement of the CNV area[1]. |
| [References]
[1] Hatcher JM, et al. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6. DOI:10.1016/j.chembiol.2018.01.013 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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