| Identification | Back Directory | [Name]
2,6-Pyridinediamine, 4-[2-methyl-3-(2,2,2-trifluoroethyl)-3H-imidazo[4,5-b]pyridin-5-yl]- | [CAS]
2091883-59-7 | [Synonyms]
Dyrk1A-IN-4
2,6-Pyridinediamine, 4-[2-methyl-3-(2,2,2-trifluoroethyl)-3H-imidazo[4,5-b]pyridin-5-yl]- | [Molecular Formula]
C14H13F3N6 | [MOL File]
2091883-59-7.mol | [Molecular Weight]
322.29 |
| Chemical Properties | Back Directory | [Boiling point ]
567.3±50.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.09±0.38(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Dyrk1A-IN-4 (compound 48) is a potent and orally active DYRK1A and DYRK2 inhibitor with IC50s of 2 nM and 6 nM, respectively. Dyrk1A-IN-4 has anticancer effects[1]. | [IC 50]
DYRK1A: 2 nM (IC50); DYRK2: 6 nM (IC50) | [References]
[1] Csaba Weber, et al. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem. 2021 May 27;64(10):6745-6764. DOI:10.1021/acs.jmedchem.1c00023 |
|
|