| Identification | More | [Name]
4-Amino-2-chlorobenzonitrile | [CAS]
20925-27-3 | [Synonyms]
3-CHLORO-4-CYANOANILINE
4-AMINO-2-CHLOROBENZONITRILE
LABOTEST-BB LT00159892
TIMTEC-BB SBB004052
4-Amino-2-chlorobenzonitrile 99%
4-AMINO-2-CHLOROBENZONITRILE, 98+% | [EINECS(EC#)]
244-114-0 | [Molecular Formula]
C7H5ClN2 | [MDL Number]
MFCD00035926 | [Molecular Weight]
152.58 | [MOL File]
20925-27-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
116-118 °C(lit.)
| [Boiling point ]
339.5±27.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
0.67±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [BRN ]
2936425 | [InChI]
1S/C7H5ClN2/c8-7-3-6(10)2-1-5(7)4-9/h1-3H,10H2 | [InChIKey]
ZFBKYGFPUCUYIF-UHFFFAOYSA-N | [SMILES]
Nc1ccc(C#N)c(Cl)c1 | [CAS DataBase Reference]
20925-27-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H317 | [Precautionary statements ]
P280 | [Hazard Codes ]
Xn,Xi,N | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
3439 | [WGK Germany ]
3
| [Hazard Note ]
Harmful/Irritant | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
2926907090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
4-Amino-2-chlorobenzonitrile is commonly used as an organic reagent. | [Synthesis]
Step 4: 2-chloro-4-nitrobenzonitrile (5 g, 0.027 mol) was mixed with hydrazine monohydrate (110 ml) and heated to reaction initiation. Subsequently, the remaining 2-chloro-4-nitrobenzonitrile (35 g, 0.192 mol) was added in batches. The reaction mixture was refluxed for about 30 min after the nitrogen release stopped completely. Upon completion of the reaction, the mixture was slowly poured into stirred ice water. The precipitate was collected by filtration and purified by recrystallization in water to give 2-chloro-4-aminobenzonitrile (25 g, 78% yield, melting point 117 °C). | [References]
[1] Patent: US4424371, 1984, A |
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