| Identification | Back Directory | [Name]
Thalidomide-C2-amido-C2-COOH | [CAS]
2353496-84-9 | [Synonyms]
Thalidomide-C2-amido-C2-COOH
Butanoic acid, 4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]amino]-4-oxo- | [Molecular Formula]
C19H20N4O7 | [MDL Number]
MFCD34469878 | [MOL File]
2353496-84-9.mol | [Molecular Weight]
416.38 |
| Chemical Properties | Back Directory | [Boiling point ]
845.1±65.0 °C(Predicted) | [density ]
1.518±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.74±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709)[1]. | [IC 50]
Cereblon | [References]
[1] Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952. DOI:10.1016/j.ejmech.2019.111952 |
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