| Identification | Back Directory | [Name]
QM385 | [CAS]
2093421-02-2 | [Synonyms]
QM385
Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 2-[5-methyl-4-[[4-(2,2,2-trifluoroethyl)-1-piperazinyl]carbonyl]-1H-pyrazol-1-yl]- | [Molecular Formula]
C17H18F3N7O2 | [MDL Number]
MFCD32174270 | [MOL File]
2093421-02-2.mol | [Molecular Weight]
409.37 |
| Chemical Properties | Back Directory | [Boiling point ]
586.1±60.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.00±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1]. | [References]
[1] Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568. DOI:10.1038/s41586-018-0701-2 |
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MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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