| Identification | Back Directory | [Name]
CAY10723 | [CAS]
2095107-57-4 | [Synonyms]
CAY10723
PAD2-IN-2
PAD2 IN 2,PAD2IN2,PAD-2-IN-2
1H-Isoindole-4-carboxamide, N-[(1S)-4-[(2-fluoro-1-iminoethyl)amino]-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-2,3-dihydro-3-oxo- | [Molecular Formula]
C24H27FN6O3 | [MOL File]
2095107-57-4.mol | [Molecular Weight]
466.51 |
| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 10 mg/ml | [form ]
Solid | [pka]
13.39±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1]. | [in vivo]
AFM-30a suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice[2]. | [IC 50]
PAD2 | [storage]
Store at -20°C | [References]
[1] Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211. DOI:10.1021/acs.jmedchem.7b00274
[2] R. Surolia, et al. Role of PAD2 Regulated Inflammasome Signaling in Arsenic Induced Airway Inflammation and Remodeling. American Journal of Respiratory and Critical Care Medicine 2020;201:A2976. |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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