| Identification | Back Directory | [Name]
1H-Isoindole-4-carboxamide, N-[(1S)-1-(4-ethoxy-1-methyl-1H-benzimidazol-2-yl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-2,3-dihydro-3-oxo- | [CAS]
2095109-82-1 | [Synonyms]
PAD2-IN-1
1H-Isoindole-4-carboxamide, N-[(1S)-1-(4-ethoxy-1-methyl-1H-benzimidazol-2-yl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-2,3-dihydro-3-oxo- | [Molecular Formula]
C25 H29 F N6 O3 | [MOL File]
2095109-82-1.mol | [Molecular Weight]
480.53 |
| Hazard Information | Back Directory | [Uses]
AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1]. | [storage]
Store at -20°C | [References]
[1] Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211. DOI:10.1021/acs.jmedchem.7b00274 |
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