| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 12.5 mg/mL (28.63 mM) | [form ]
Solid | [pka]
7.40±0.53(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability[1]. | [in vivo]
HSL-IN-1 (3 mg/kg, p.o., single dose) exhibits potent antilipolytic effects and good oral bioavailability in male Wistar rats[1]. | Animal Model: | Male Wistar rats (7-8 weeks old, 200-250 g)[1] | | Dosage: | 3 mg/kg | | Administration: | Oral gavage (p.o.), single dose | | Result: | Significantly reduced plasma glycerol levels.
Cmax was 3.35 μg/mL, and AUC was 19.65 μg·h/mL. |
| [References]
[1] Ogiyama T, et al. Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation. Bioorg Med Chem. 2017 Apr 1;25(7):2234-2243. DOI:10.1016/j.bmc.2017.02.045 |
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