| Identification | Back Directory | [Name]
Methanone, [(3R)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl](6-bromopyrazolo[1,5-a]pyridin-3-yl)- | [CAS]
2095484-82-3 | [Synonyms]
(R)-eIF4A3-IN-2
Methanone, [(3R)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl](6-bromopyrazolo[1,5-a]pyridin-3-yl)- | [Molecular Formula]
C25H19Br2ClN4O2 | [MDL Number]
MFCD32670878 | [MOL File]
2095484-82-3.mol | [Molecular Weight]
602.71 |
| Hazard Information | Back Directory | [Uses]
(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1]. | [storage]
Store at -20°C | [References]
[1] Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017;12(7):1760-1768. DOI:10.1021/acschembio.7b00041 |
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