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2411681-88-2

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2411681-88-2 Structure

2411681-88-2 Structure
IdentificationBack Directory
[Name]

Thalidomide-O-PEG4-NHS ester
[CAS]

2411681-88-2
[Synonyms]

Thalidomide-O-PEG4-NHS ester
[Molecular Formula]

C28H33N3O13
[MDL Number]

MFCD32670310
[MOL File]

2411681-88-2.mol
[Molecular Weight]

619.57
Chemical PropertiesBack Directory
[density ]

1.45±0.1 g/cm3(Predicted)
[solubility ]

Soluble in DCM
[form ]

Oil
[pka]

10.70±0.40(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[HS Code ]

2933998090
Hazard InformationBack Directory
[Description]

Thalidomide-O-PEG4-NHS ester is a synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology it is reactive with amine moiety.
[Uses]

Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

Cereblon
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Spectrum DetailBack Directory
[Spectrum Detail]

Thalidomide-O-PEG4-NHS ester(2411681-88-2)1HNMR
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