| Identification | Back Directory | [Name]
N-(Acid-PEG2)-N-bis(PEG2-propargyl) | [CAS]
2100306-49-6 | [Synonyms]
N-(Acid-PEG2)-N-bis(PEG2-propargyl)
N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) | [Molecular Formula]
C21H35NO8 | [MDL Number]
MFCD30723247 | [MOL File]
2100306-49-6.mol | [Molecular Weight]
429.5 |
| Chemical Properties | Back Directory | [Boiling point ]
533.6±50.0 °C(Predicted) | [density ]
1.122±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
4.27±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Acid-PEG2)-N-bis(PEG2-propargyl) is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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