| Identification | Back Directory | [Name]
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt | [CAS]
2093153-09-2 | [Synonyms]
QUN 53092
N-(Propargyl-peg4)-n-bis(peg4-acid)
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt | [Molecular Formula]
C33H61NO16 | [MDL Number]
MFCD30723276 | [MOL File]
2093153-09-2.mol | [Molecular Weight]
727.835 |
| Chemical Properties | Back Directory | [Boiling point ]
765.0±60.0 °C(Predicted) | [density ]
1.155±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
3.97±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a branched crosslinking reagent with a propargyl group and two terminal carboxylic acids. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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