| Identification | Back Directory | [Name]
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester | [CAS]
2100306-76-9 | [Synonyms]
ZWN 06769
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester | [Molecular Formula]
C30H54N6O11S | [MDL Number]
MFCD31692206 | [MOL File]
2100306-76-9.mol | [Molecular Weight]
706.85 |
| Hazard Information | Back Directory | [Description]
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a branched PEG linker with a biotin group and terminal azide group. The azide group enables click chemistry. | [Uses]
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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