| Identification | Back Directory | [Name]
Biotin-PEG6-azide | [CAS]
1085938-09-5 | [Synonyms]
Biotin-PEG6-N3
Biotin-PEG6-azide
Biotin-PEG6-CH2CH2N3 | [Molecular Formula]
C24H44N6O8S | [MDL Number]
MFCD31693707 | [MOL File]
1085938-09-5.mol | [Molecular Weight]
576.71 |
| Hazard Information | Back Directory | [Description]
Biotin-PEG6-azide is PEG containing biotin reagent that cn be used for bioconjugation | [Uses]
Biotin-PEG6-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
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