| Identification | Back Directory | [Name]
Biotin-PEG4-Azide | [CAS]
1309649-57-7 | [Synonyms]
(+)-Biotin-PEG4-CH2CH2N3
Biotin-PEG4-azide,Biotin-PEG4-N3
N-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]biotinamide
N-(14-Azido-3,6,9,12-tetraoxatetradecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | [Molecular Formula]
C20H36N6O6S | [MDL Number]
MFCD29495433 | [MOL File]
1309649-57-7.mol | [Molecular Weight]
488.601 |
| Hazard Information | Back Directory | [Description]
Biotin-PEG4-azide is a very useful biotinylation reagent that enable Click Chemistry reaction with alkyne, such as Propargyl, DBCO or BCN reagent to form a stable bond. PEG4 spacer increases aqueous solubility of the molecules conjugated to the biotin. It also helps to minimize steric hindrance involved with the binding to avidin molecules. | [Uses]
Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
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