| Identification | Back Directory | [Name]
Hydroxy-PEG5-methyl ester | [CAS]
2100306-80-5 | [Synonyms]
HO-PEG5-COOMe
CAS_2100306-80-5
Hydroxy-PEG5-methyl ester
Hydroxy-PEG5-C2-methyl ester
4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-hydroxy-, methyl ester | [Molecular Formula]
C14H28O8 | [MDL Number]
MFCD30730370 | [MOL File]
2100306-80-5.mol | [Molecular Weight]
324.37 |
| Chemical Properties | Back Directory | [Boiling point ]
414.8±40.0 °C(Predicted) | [density ]
1.109±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG5-methyl ester is a PEG linker containing a hydroxyl group and a methyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Methyl ester can be hydrolyzed under strong basic condition. | [Uses]
Hydroxy-PEG5-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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