| Identification | Back Directory | [Name]
Propanoic acid, 3-[2-[2-[2-[[2-(2-cyclooctyn-1-yloxy)acetyl]amino]ethoxy]ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester | [CAS]
2101206-33-9 | [Synonyms]
Cyclooctyne-O-amido-PEG3-PFP ester
Propanoic acid, 3-[2-[2-[2-[[2-(2-cyclooctyn-1-yloxy)acetyl]amino]ethoxy]ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester | [Molecular Formula]
C25H30F5NO7 | [MDL Number]
MFCD28899320 | [MOL File]
2101206-33-9.mol | [Molecular Weight]
551.5 |
| Hazard Information | Back Directory | [Uses]
Cyclooctyne-O-amido-PEG3-PFP ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Cyclooctyne-O-amido-PEG3-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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