| Identification | Back Directory | [Name]
angoline | [CAS]
21080-31-9 | [Synonyms]
angoline
6-Methoxyldihydrochelerythrine
12,13-Dihydro-1,2,13-trimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine
[1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2,13-trimethoxy-12-methyl- | [Molecular Formula]
C22H21NO5 | [MDL Number]
MFCD31557277 | [MOL File]
21080-31-9.mol | [Molecular Weight]
379.41 |
| Hazard Information | Back Directory | [Description]
The empirical formula of this alkaloid should read C21 H21 NO5 | [Uses]
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. | [Definition]
ChEBI: Angoline is a benzophenanthridine alkaloid. | [storage]
4°C, protect from light | [References]
[1] Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91. DOI:10.1016/j.phymed.2014.04.001 |
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