| Identification | Back Directory | [Name]
Ethoxysanguinarine | [CAS]
28342-31-6 | [Synonyms]
Ethoxysanguinarine
6-Ethoxysanguinarine
6-Ethoxydihydrosanguinarine
Ethoxysanguinarine Stemonine
14-Ethoxy-13,14-dihydrosanguinarine
($$+/-$$)-Sanguinarine pseudoethanolate
14-Ethoxy-13,14-dihydrosanguinarine
(±)-Sanguinarine pseudoethanolate
Ethoxysanguinarine/6-Ethoxysanguinarine/6-Ethoxydihydrosanguinarine/(±)-Sanguinarine pseudoethanolate
14-Ethoxy-13-Methyl-13,14-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine | [Molecular Formula]
C22H19NO5 | [MDL Number]
MFCD09953808 | [MOL File]
28342-31-6.mol | [Molecular Weight]
377.39 |
| Chemical Properties | Back Directory | [Melting point ]
210-212℃ (ethanol ) | [Boiling point ]
563.7±50.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
0.59±0.40(Predicted) | [color ]
White to yellow | [InChI]
InChI=1S/C22H19NO5/c1-3-24-22-19-13(6-7-16-21(19)28-11-25-16)14-5-4-12-8-17-18(27-10-26-17)9-15(12)20(14)23(22)2/h4-9,22H,3,10-11H2,1-2H3 | [InChIKey]
FCEXWTOTHXCQCQ-UHFFFAOYSA-N | [SMILES]
C1=C2C(N(C)C(OCC)C3=C2C=CC2OCOC3=2)=C2C=C3OCOC3=CC2=C1 |
| Hazard Information | Back Directory | [Uses]
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth[1]. | [in vivo]
Ethoxysanguinarine (0.5 mg/kg; s.c.; 5 times per week; 4 weeks) represses colorectal cancer (CRC) xenograft tumors growth in mice[1]. | Animal Model: | Nude immunodeficient mice (5-week-old, weighing about 16 g)[1] | | Dosage: | 0.5 mg/kg | | Administration: | Subcutaneous injection; 5 times per week for 4 weeks | | Result: | Exhibited antitumor effects without reduce the body weight of the mice. |
| [storage]
4°C, protect from light | [References]
[1] Jin L, et al. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A. Int J Oncol. 2018 Mar 16. DOI:10.3892/ijo.2018.4323 |
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