| Identification | Back Directory | [Name]
CP-424,174 | [CAS]
210825-31-3 | [Synonyms]
CP-424,174
CP-424,174 >=98% (HPLC)
N-((4-Chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide
CP424174,IL-1β,NLRP3,Inhibitor,CP 424174,CP-424174,Inflammasome,inhibit,NOD-like Receptor (NLR)
N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Benzenesulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)- | [Molecular Formula]
C22H29ClN2O4S | [MDL Number]
MFCD30537538 | [MOL File]
210825-31-3.mol | [Molecular Weight]
452.99 |
| Chemical Properties | Back Directory | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml | [form ]
powder | [pka]
4.67±0.10(Predicted) | [color ]
white to beige | [InChI]
1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26) | [InChIKey]
YRSBLSHMKVQWHP-UHFFFAOYSA-N | [SMILES]
CC(O)(C)C1=CC(S(=O)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O)=CC=C1 |
| Hazard Information | Back Directory | [Uses]
CP-424174 is a reversible inhibitor against IL-1β processing with an IC50 of 210 nM.CP-424174 indirectly inhibits NLRP3[1]. | [Biochem/physiol Actions]
CP-424,174 is a cytokine release inhibitory drugs (CRID) that inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. It is quite possible that similarly to CP-456,773 (termed CRID3), CP-424,174 inhibits both NLRP3 and AIM2 inflammasomes by preventing ASC oligomerisation. | [References]
[1] Alex G Baldwin, et al. Inhibiting the Inflammasome: A Chemical Perspective. J Med Chem DOI:10.1021/acs.jmedchem.5b01091 |
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