| Identification | Back Directory | [Name]
TH 1834 | [CAS]
2108830-08-4 | [Synonyms]
TH 1834
2H-Tetrazole-2-acetic acid, 5-[4-[[(2-phenylethyl)[4-[4-(1-pyrrolidinylmethyl)phenoxy]butyl]amino]methyl]phenyl]- | [Molecular Formula]
C33H40N6O3 | [MDL Number]
MFCD32701916 | [MOL File]
2108830-08-4.mol | [Molecular Weight]
568.71 |
| Chemical Properties | Back Directory | [Boiling point ]
750.4±70.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.91±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. | [IC 50]
TIP60 | [References]
[1] Gao C, et al. Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep. 2014 Jun 20;4:5372. DOI:10.1038/srep05372 |
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