| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: 2 mg/mL, clear | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
H2O: 2mg/mL, clear | [InChIKey]
HYXIFSOROZPMMU-UHFFFAOYSA-N | [SMILES]
O=C(O)CN1N=C(C2=CC=C(CN(CCC3=CC=CC=C3)CCCCOC4=CC=C(CN5CCCC5)C=C4)C=C2)N=N1.[H]Cl.[H]Cl |
| Hazard Information | Back Directory | [Description]
TH1834 HCl is a Tip60 histone acetyltransferase inhibitor. | [Uses]
TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. | [IC 50]
TIP60 | [References]
[1] Gao C, et al. Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep. 2014 Jun 20;4:5372. DOI:10.1038/srep05372 |
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