| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG8-propargyl | [CAS]
2183440-31-3 | [Synonyms]
Propargyl-PEG8-NHBoc
Boc-NH-PEG8-propargyl
Propargyl-PEG9-Boc Amine
t-Boc-N-Amido-PEG8-propargyl | [Molecular Formula]
C24H45NO10 | [MDL Number]
MFCD31561113 | [MOL File]
2183440-31-3.mol | [Molecular Weight]
507.61 |
| Chemical Properties | Back Directory | [Boiling point ]
565.0±50.0 °C(Predicted) | [density ]
1.076±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
12.23±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG8-propargyl has an alkyne group and Boc-protected amine. The alkyne group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The deprotection of Boc-protected amine can be peformed under mild acidic conditions. The hydrophilic PEG chain enhances the solubility of the molecule in aqueous solution. | [Uses]
Boc-NH-PEG8-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG8-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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