| Identification | Back Directory | [Name]
Benzoic acid, 4-[5-[(1E)-2-cyano-3-[(4-cyano-3-fluorophenyl)amino]-3-oxo-1-propen-1-yl]-2-furanyl]- | [CAS]
2128651-12-5 | [Synonyms]
SIRT5 inhibitor 3
Benzoic acid, 4-[5-[(1E)-2-cyano-3-[(4-cyano-3-fluorophenyl)amino]-3-oxo-1-propen-1-yl]-2-furanyl]- | [Molecular Formula]
C22H12FN3O4 | [MOL File]
2128651-12-5.mol | [Molecular Weight]
401.35 |
| Chemical Properties | Back Directory | [Boiling point ]
700.4±60.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.09±0.10(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
SIRT5 inhibitor 3 (compound 46) is a potent and competitive SIRT5 inhibitor with an IC50 value of 5.9 μM. SIRT5 inhibitor 3 can inhibit SIRT5 desuccinylation. SIRT5 inhibitor 3 can be used for researching cancer and neurodegenerative diseases[1]. | [IC 50]
SIRT5: 5.9 μM (IC50) | [References]
[1] Wang Y, et al. Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem. 2022;236:114363. DOI:10.1016/j.ejmech.2022.114363 |
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