| Chemical Properties | Back Directory | [Boiling point ]
788.1±60.0 °C(Predicted) | [density ]
1.163±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
12.23±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
Mal-amido-PEG9-NHBoc is a PEG linker containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-amido-PEG9-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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