| Identification | More | [Name]
Boc-O-benzyl-L-tyrosine | [CAS]
2130-96-3 | [Synonyms]
BOC-L-TYR(BZL)-OH
BOC-O-BENZYL-L-TYR
BOC-O-BENZYL-L-TYROSINE
BOC-(S)-2-AMINO-3-(4'-BENZYLOXYPHENYL)PROPANOIC ACID
BOC-TYR(BZL)
BOC-TYR(BZL)-OH
BOC-TYROSINE(BZL)-OH
N-ALPHA-T-BOC-O-BENZYL-L-TYROSINE
N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-TYROSINE
N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-L-TYROSINE
N-BOC-O-BENZYL-L-TYROSINE
N-T-BUTOXYCARBONYL-O-BENZYL-L-TYROSINE
N-TERT-BUTOXYCARBONYL-O-BENZYL-L-TYRISINE
N-(TERT-BUTOXYCARBONYL)-O-BENZYL-L-TYROSINE
T-BUTYLOXYCARBONYL-O-BENZYL-L-TYROSINE
Butoxycarbonylbenzyltyrisine
N-T-boc-O-benzyl-L-tyrosine crystalline
O-benzyl-N-[(tert-butoxy)carbonyl]-L-tyrosine
Boc-L-Tyr(Bzl)
N-ALPHA-TERT-BUTYLOXYCABONYL-O-BENZYL-L-TYROSINE | [EINECS(EC#)]
218-349-4 | [Molecular Formula]
C21H25NO5 | [MDL Number]
MFCD00065597 | [Molecular Weight]
371.43 | [MOL File]
2130-96-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
110-112 °C | [alpha ]
27 º (c=2% in ethanol) | [Boiling point ]
552.4±50.0 °C(Predicted) | [density ]
1.185±0.06 g/cm3(Predicted) | [refractive index ]
29.5 ° (C=2, EtOH) | [storage temp. ]
2-8°C
| [solubility ]
almost transparency in EtOH | [form ]
Powder or Crystalline Powder | [pka]
2.99±0.10(Predicted) | [color ]
White | [Optical Rotation]
[α]20/D +27.0±1.5°, c = 2% in ethanol | [BRN ]
2227416 | [Major Application]
peptide synthesis | [InChI]
1S/C21H25NO5/c1-21(2,3)27-20(25)22-18(19(23)24)13-15-9-11-17(12-10-15)26-14-16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3,(H,22,25)(H,23,24)/t18-/m0/s1 | [InChIKey]
ZAVSPTOJKOFMTA-SFHVURJKSA-N | [SMILES]
CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(O)=O | [CAS DataBase Reference]
2130-96-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29242990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
Boc-Tyr(Bzl)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance. | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis | [Synthesis]
Example 2: To a solution of N-Boc-L-tyrosine (281 mg, 1.0 mmol) in methanol (0.5 mL) was added 28% sodium methanol-methanol solution (0.42 mL, 2.1 mmol) and benzyl bromide (162 μL, 1.4 mmol). The reaction mixture was stirred at 40 °C for 3 hours. After completion of the reaction, water (2 mL) was added to homogenize the system and the reaction system was analyzed by high performance liquid chromatography (HPLC). The analysis confirmed the generation of the target product (S)-3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)propionic acid (353 mg, 95% conversion). | [References]
[1] Patent: US2005/283021, 2005, A1. Location in patent: Page/Page column 6
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 14, p. 3057 - 3062
[3] European Journal of Medicinal Chemistry, 2016, vol. 114, p. 318 - 327
[4] Patent: CN107954937, 2018, A. Location in patent: Paragraph 0032-0034 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
AF Biochem Co., Ltd.
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+86-028-60911900 13540204019 |
| Website: |
www.afbiochem.com |
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