| Company Name: |
Alfa Aesar |
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400-6106006 |
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- Boc-Tyr-OH
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-
2026-09-17
- CAS:3978-80-1
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 500kgs
- Boc-L-Tyr-OH
-
-
2026-09-17
- CAS:3978-80-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
- BOC-L-Tyrosine
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-
2026-06-30
- CAS:3978-80-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | BOC-L-Tyrosine Basic information |
| | BOC-L-Tyrosine Chemical Properties |
| Melting point | 133-135 °C(lit.) | | alpha | 2.5 º (c=2, acetic acid) | | Boiling point | 423.97°C (rough estimate) | | density | 1.1755 (rough estimate) | | refractive index | 1.5230 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Sparingly) | | pka | 2.98±0.10(Predicted) | | form | Powder | | color | White to off-white | | Optical Rotation | [α]20/D +3.0°, c = 2 in acetic acid | | BRN | 2816406 | | Major Application | peptide synthesis | | InChI | InChI=1S/C14H19NO5/c1-14(2,3)20-13(19)15-11(12(17)18)8-9-4-6-10(16)7-5-9/h4-7,11,16H,8H2,1-3H3,(H,15,19)(H,17,18)/t11-/m0/s1 | | InChIKey | CNBUSIJNWNXLQQ-NSHDSACASA-N | | SMILES | C(O)(=O)[C@H](CC1=CC=C(O)C=C1)NC(OC(C)(C)C)=O | | CAS DataBase Reference | 3978-80-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-36-26 | | WGK Germany | 3 | | HS Code | 29242990 | | Storage Class | 11 - Combustible Solids |
| | BOC-L-Tyrosine Usage And Synthesis |
| Chemical Properties | white to off-white powder | | Uses | N-Boc-L-tyrosine is an N-Boc-protected form of L-Tyrosine (T899975). L-Tyrosine is an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones. | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | Synthesis | In a dry 50 mL round-bottomed flask, (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid ( 200 mg) was dissolved in dry 1,4 -dioxane ( 10 mL) and H2O (5 mL) ( 2:1 ). NaOH ( 1 M, 5 mL, 5 mmol, 4.5 eq.) and Boc2O ( 0.28 mL, 1.21 mmol) were then added sequentially to the solution. The resulting reaction mixture was stirred at room temperature for 3 h. The progress of the reaction was monitored by LCMS and after waiting for the end of the reaction the reaction solution was acidified with 2 M HCl to a pH of about 2 - 3. The resulting reaction mixture was extracted three times with ethyl acetate ( 3 25 mL), all the organic layers were combined and the organic layer was washed with brine, the organic layer was separated out and dried with anhydrous Na2SO4, the organic layer was filtered to remove the drying agent, and the resulting organic layer was dried with anhydrous Na2SO4. The organic layer was separated and dried with anhydrous Na2SO4, the organic layer was filtered to remove the desiccant, and the resulting filtrate was concentrated under vacuum to remove the organic solvent, and the crude product was separated and purified by silica gel column chromatography to obtain the target product molecule, N-tert-butoxycarbonyl-L-tyrosine. |
| | BOC-L-Tyrosine Preparation Products And Raw materials |
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