| Identification | Back Directory | [Name]
(2-pyridyldithio)-PEG2-t-butyl ester | [CAS]
2144777-73-9 | [Synonyms]
(2-Pyridyldithio)-PEG2-Boc
(2-pyridyldithio)-PEG2-t-butyl ester | [Molecular Formula]
C16H25NO4S2 | [MDL Number]
MFCD31561120 | [MOL File]
2144777-73-9.mol | [Molecular Weight]
359.5 |
| Chemical Properties | Back Directory | [Boiling point ]
462.8±45.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [form ]
Liquid | [pka]
1.81±0.19(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
(2-pyridyldithio)-PEG2-t-butyl ester is a PEG linker which contains a pyridyl disulfide moiety and a t-butyl ester group. The pyridyl disulfide group can react with thiol groups of proteins over a wide range of pH level. The t-butyl ester group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound. | [Uses]
(2-Pyridyldithio)-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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