| Identification | Back Directory | [Name]
(2-pyridyldithio)-PEG4-alcohol | [CAS]
851961-99-4 | [Synonyms]
(2-pyridyldithio)-PEG4-alcohol
Ethanol, 2-[2-[2-[2-(2-pyridinyldithio)ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C13H21NO4S2 | [MDL Number]
MFCD31561123 | [MOL File]
851961-99-4.mol | [Molecular Weight]
319.44 |
| Hazard Information | Back Directory | [Description]
(2-pyridyldithio)-PEG2-alcohol is a PEG linker which contains a pyridyl disulfide moiety and an alcohol group. The pyridyl disulfide group can react with thiol groups of proteins over a wide range of pH level. The hydroxyl group allows for further derivatization of the compound. The hydrophilic PEG linker increases the water solubility of the compound. | [Uses]
(2-Pyridyldithio)-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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