| Identification | Back Directory | [Name]
1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- | [CAS]
214770-19-1 | [Synonyms]
976
L779976
L-779976
L 779976
1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- | [Molecular Formula]
C33H43N7O3 | [MOL File]
214770-19-1.mol | [Molecular Weight]
585.75 |
| Hazard Information | Back Directory | [Uses]
L-779976 is a compound with bradykinin agonist activity. Injection into the amygdala and septum of the rat brain can produce anxiolytic effects. Its bradykinin agonist activity has been verified by relevant experiments. | [Definition]
ChEBI: L-779976 is a member of the class of indoles that is (betaS)-beta-methyl-D-tryptophan in which the primary amino group undergoes formal condensation with the carboxy group of 4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1-carboxylic acid and the carboxy group undegoes formal condensation with the amino group of (1R,3S)-cyclohexane-1,3-diyldimethanamine. It is a selective nonpeptidic agonist of the somatostatin subtype-2 (SST2) receptor with Ki of 0.05 nM. It has a role as a somatostatin receptor agonist and a neuroprotective agent. It is a secondary carboxamide, a primary amino compound, a member of indoles, a member of benzimidazoles and a piperidinecarboxamide. | [References]
[1] The anxiolytic effects of somatostatin following intra-septal and intra-amygdalar microinfusions are reversed by the selective sst2 antagonist PRL2903 DOI:10.1016/j.pbb.2011.12.012 |
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